Pharmacokinetic Characteristics of a Nifedipine and Lidocaine Fixed Combination in the Form of Rectal Cream: Two Decades Data Analysis

The creation of medicines' fixed combinations from compounds with complementary effects is one the most popular directions in modern pharmacology and pharmaceutics. In case nifedipine lidocaine combination such approach quite obvious. present review article devoted to analysis clinical non-clinical studies results on assessment pharmacokinetic characteristics these medicines. Although oral route convenient for drug administration, there are a number circumstances where this not possible either or pharmaceutical perspective. cases, rectal may represent practical alternative can be used administer drugs both local systemic actions. Research data last decades suggested that nifedipine, calcium channel blocker, could effective reducing anal resting pressure healing chronic fissure acute thrombosed hemorrhoids. Another component anesthetic usually relieve pain fissures symptomatic have Analysis all available (during 2 decades) which were aimed investigate form cream showed following topical application, active ingredients absorbed into bloodstream only small quantities no major implications safety product, absorption, if any, was incomparably lower than absorption per os administration two ingredients.